Undiagnosed Myasthenia Gravis Complicating Operative Course of Patient Posted for Diagnostic Laryngoscopy and Biopsy

Introduction: Myasthenia gravis is a chronic autoimmuneneuromuscular disease characterised by varying degree ofmuscle weakness. Undiagnosed myasthenia gravis owing tovery unusual presentation in perioperative period leading tosignificant complications.Case report: A case report of undiagnosed myasthenia gravispatient presented for direct laryngoscopy and biopsy, withcomplaint of dysphagia and jaw pain.Conclusion: Myasthenia gravis is an autoimmune diseaseand may be detected accidentally. And care should be paidto possible complications because of neuromuscular blockingagents.

Anesthetic Nuances In A Hypertrophic Cardiomyopathy Patient For Laparoscopic Abdominoperineal Resection

Hypertrophic cardiomyopathy is a complex cardiac disease with unique pathophysiologic characteristics and a great diversity of morphologic, functional, and clinical features. It is characterized by a massive asymmetrical hypertrophy of the myocardium. Clinical features range from an absence of symptoms to sudden death. We report a rare case of a 57-year-old male presenting with a history of constipation for 3 months, weight loss and fatigue for 3 months, and blood in stools for 1 month. He was diagnosed with a carcinoma rectum. He was planned for abdominoperineal resection by laparoscopic approach. Aim of this case report is to discuss the challenging technical nuances of anesthetic management of a patient with hypertrophic cardiomyopathy posted for laparoscopic surgery

Genetic underpinnings of lung function and COPD

Spirometry based measurement of lung function is a global initiative for chronic obstructive lung disease (GOLD) standard to diagnose chronic obstructive pulmonary disease (COPD), one of the leading causes of mortality worldwide. Theenvironmental and behavioural risk factors for COPD includes tobacco smoking, air pollutants and biomass fuel exposure, which can induce one or more abnormal lung function patterns. While smoking remains the primary risk factor, only 15–20% smokers develop COPD, indicating that the genetic factors are also likely to play a role. According to the study of Global Burden of Disease 2015, ∼174 million people across the world have COPD. From a comprehensive literature search conducted using the ‘PubMed’ and ‘GWAS Catalogue’ databases, and reviewing the literature available, only a limited number of studies were identified which hadattempted to investigate the genetics of COPD and lung volumes, implying a huge research gap. With the advent of genomewide association studies several genetic variants linked to lung function and COPD, like HHIP, HTR4, ADAM19 and GSTCD etc., have been found and validated in different population groups, suggesting their potential role in determining lung volume and risk for COPD. This article aims at reviewing the present knowledge of the genetics of lung function and COPD

Complexity of rice Hsp100 gene family: lessons from rice genome sequence data.

Elucidation of genome sequence provides an excellent platform to understand detailed complexity of the various gene families. Hsp100 is an important family of chaperones in diverse living systems. There are eight putative gene loci encoding for Hsp100 proteins in Arabidopsis genome. In rice, two full-length Hsp100 cDNAs have been isolated and sequenced so far. Analysis of rice genomic sequence by in silico approach showed that two isolated rice Hsp100 cDNAs correspond to Os05g44340 and Os02g32520 genes in the rice genome database. There appears to be three additional proteins (encoded by Os03g31300, Os04g32560 and Os04g33210 gene loci) that are variably homologous to Os05g44340 and Os02g32520 throughout the entire amino acid sequence. The above five rice Hsp100 genes show significant similarities in the signature sequences known to be conserved among Hsp100 proteins. While Os05g44340 encodes cytoplasmic Hsp100 protein, those encoded by the other four genes are predicted to have chloroplast transit peptides.